Barry j marshall biography definition

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Barry James Marshall, AC, FRS, FAA (born 30 September 1951) is an Australiandoctor and winner of the 2005 Nobel Prize in Physiology or Medicine. He is Professor of Clinical Microbiology at the University of Western Australia. Marshall is well known for proving that bacteriaHelicobacter pylori are the cause of most stomach ulcers. This changed years of medical belief which said that ulcers were caused by stress, spicy foods, and too much acid. He took a part-time position at the Pennsylvania State University in 2007.

Early years

Marshall was born in Kalgoorlie, Western Australia. He lived in Kalgoorlie and Carnarvon until moving to Perth at the age of seven. He went to high school at Newman College, Perth. At the University of Western Australia, medicine and surgery. He married his wife, Adrienne, in 1972. In 1972 he was also the Western Australian state yo-yo champion.

Life and research

In 1979 Marshall became a Registrar in Medicine at the Royal Perth Hospital. At the hospital he met Robin Warren, a pathologist who was interested in gastritis. They were both training in internal medicine at Royal Perth Hospital in 1981. Together they looked at spiral bacteria in gastritis. In 1982 they grew a culture of H. pylori. They worked on their idea that there was a bacterial cause of peptic ulcer and stomachcancer. Their idea was laughed at by scientists and doctors who did not believe that any bacteria could live in the acidic stomach. Marshall said that "Everyone was against me, but I knew I was right". Other doctors said they wouldn't believe it until the H. pylori idea could be proved.

Marshall and Warren tried to give the bacteria to piglets in 1984, but it did not work. Marshall drank some of the bacteria and soon developed gastritis with achlorhydria. He had stomach discomfort, nausea, vomiting and bad sme

Australian physician

Barry Marshall was born in Perth, Australia. He is a physician with a clinical and research interest in gastroenterology. He is internationally recognized for his discovery that the bacterium Helicobacter pylori is the major cause of stomach ulcers.

Marshall studied medicine at the University of Western Australia from 1969 to 1974. While studying for his medical degree, Marshall decided to pursue medical research. He undertook research in the laboratory of Dr. Robin Warren, who had observations of a helical bacteria in the stomach of people suffering from ulcers.

Marshall and Warren succeeded in culturing the bacterium, which they named Helicobacter pylori. Despite their evidence that the organism was the cause of stomach ulceration, the medical community of the time was not convinced that a bacterium could survive the harsh acidic conditions of the stomach yet alone cause tissue damage in this environment. In order to illustrate the relevance of the bacterium to the disease, Marshall performed an experiment that has earned him international renown. In July of 1984, he swallowed a solution of the bacterium, developed the infection, including inflammation of the stomach, and cured himself of both the infection and the stomach inflammation by antibiotic therapy.

By 1994, Marshall's theory of Helicobacter involvement in stomach ulcers was accepted, when the United StatesNational Institutes of Health endorsed antibiotics s the standard treatment for stomach ulcers.

Since Marshall's discovery, Helicobacter pylori has been shown to be the leading cause of stomach and intestinal ulcers, gastritis and stomach cancer. Many thousands of ulcer patients around the world have been successfully treated by strategies designed to attack bacterial infection . Marshall's finding was one of the first indications that human disease thought to be due to biochemical or genetic defects were in fact due to bacteri

In 2005, Barry Marshall and Robin Warren were awarded the Nobel prize in Physiology for their pioneering work on Helicobacter pylori. In the words of the Nobel Committee, they were honored “for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease.” The Committee added, “Thanks to the pioneering discovery by Marshall and Warren, peptic ulcer disease is no longer a chronic, frequently disabling condition, but a disease that can be cured by a short regimen of antibiotics and acid secretion inhibitors.”

Today, Barry Marshall is the National Health Medical Research Council Senior Principal Research Fellow at the University of Western Australia. In recent years, his research has illuminated the patterns of Helicobacter infection in different populations around the world. It is probably the most widespread chronic infection in the world, and is nearly universal in the world’s poorest countries. Dr Marshall hopes to see the insidious corkscrew organism controlled to the point where it can no longer pose a threat to the life and health of men, women and children anywhere in the world. Dr Marshall continues to practice as a gastroenterologist in Perth, Australia.

PA: Can you remind us of the details of the famous story of you ingesting H pylori? Did it occur to you that there is a legacy of self-experimentation in medical history such as Marie Curie?

BM: I was aware of famous self-experiments because I read the history of John Hunter’s self-infection with gonorrhea and syphilis (which may have caused his death years later). However, I had been arguing with the skeptics for two years and had no animal model that could prove H pylori was a pathogen. If I was right, then anyone was susceptible to the bug and would develop gastritis and maybe an ulcer years later. So I expected to develop an asymptomatic infection. The experiment was planned with a culture from a patient with dyspepsia